Tolerance to most of the effects of codeine, together with its therapeutic results, develops with extended use. This happens at unique fees for various outcomes, with tolerance for the constipation-inducing effects building specially gradually By way of example.It is because it is tricky to modify the dose to match the extent of your respective ago

For even further information about this treatment method and probable Negative effects go to the electronic Medicines Compendium (eMC) Web page. You can find the client info leaflet on this Site.When It really is taken with other substances, it could prevent it doing what it's speculated to do and this may possibly consequence to adverse outcomes.